General Control, Prometheus, Gemini 3, π*0.6 & Sunday Act-1, Rainmaker, Artifacts, Regulation
| Date | Post | Archived |
|---|---|---|
| 2025-11-21 |
Weekly Dose of Optimism #171
General Control, Prometheus, Gemini 3, π*0.6 & Sunday Act-1, Rainmaker, Artifacts, Regulation
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| 2025-11-14 |
Weekly Dose of Optimism #170
Episteme, Terranova, Valar Atomics, Elon's Factories, Blue Origin + Solar Two Ways
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| 2025-11-11 |
The Company as a Machine for Doing Stuff
You have the right to work only but never to its fruits.
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| 2025-11-07 |
Weekly Dose of Optimism #169
BIG WEEK IN SPACE, Poseidon, Vulcan's $1.4B, Antibody Design, Chinese TMSR, Aquarius Economy, Space DJ, and Three Things I enjoyed
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| 2025-10-31 |
Weekly Dose of Optimism #168
Substrate, Extropic, Super Hot Geothermal, Compact Nuclear, NEO House Robot + J. Storrs Hall and Skunk Works' X-59
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| 2025-10-30 |
Take Weird Ideas Seriously
Weird Ideas as Individual Alpha and Societal Necessity
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| 2025-10-24 |
Weekly Dose of Optimism #167
Science v Blindness, Google Quantum, Nucleus & Anthrogen Models, Apex Interceptors, Recoding America + Composer AI & Guardian of Liberty
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| 2025-10-17 |
Weekly Dose of Optimism #166
American Banking, Google DeepMind takes on Cancer and Fusion, Levin on Aging, California Forever, Nuclear, Stern on Kushner, Telephathy Tapes S2, Potter…
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| 2025-10-10 |
Weekly Dose of Optimism #165
Dan's Last Dose, Peace, Nobel, Brain Model, Figure 03, Base Power Company, David Lynch
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| 2025-10-03 |
Weekly Dose of Optimism #164
Planet, space deliveries, delivery robots, AI scientists, bioelectricity, and bone glue
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| 2025-10-01 |
Thatch
Curing American healthcare through incentives and choice
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| 2025-09-26 |
Weekly Dose of Optimism #163
Germinal (+bridge recombinase), cryo organs, Sila anodes, brain is not computer, hallucination-less psychedelics + Nate the Great
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| 2025-09-19 |
Weekly Dose of Optimism #162
Meta Ray-Ban Display, World Labs, Waymo Safety, Colossus 2, Delphi-2M, Ambrook
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| 2025-09-12 |
Weekly Dose of Optimism #161
Sapphire Canyon, Direct to Cell, Alterego, Soft Robots, Jetson Aero, AI Stuff
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| 2025-09-09 |
Ramp at $1 Billion
Saving Time, Compounding Over Time, Fighting Time
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| 2025-09-05 |
Weekly Dose of Optimism #160
Epigenetic atlas, Stroke Pills, Tempo, 1 GB Kuiper, Polymarket in the USA, Saquon
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| 2025-08-29 |
Weekly Dose of Optimism #159
The Kelces, Starship, Pediatric CRISPR Cures, Nano Banana, Base, Electric Slide
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| 2025-08-26 |
The Electric Slide
The history, 99% decline, and future of the Electric Stack with Sam D'Amico
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| 2025-08-22 |
Weekly Dose of Optimism #158
Astro Mechanica, Convoke, Bloom Patterns, Electrochemical Nuclear, Mark Bertolini and Joe Liemandt
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| 2025-08-15 |
Weekly Dose of Optimism #157
Advanced Nuclear, Vulcan Elemants, Rainmaker, Climate Catastrophism, AI-Designed Antibiotics + The Origins of Efficiency
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| 2025-08-08 |
Weekly Dose of Optimism #156
Standard Nuclear, GPT-5, Genie 3, Eleven Music, Lithium Orotate
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| 2025-08-01 |
Weekly Dose of Optimism #155
Personal Superintelligence, Iron-Air Batteries, OpenCRISPR-1, Figma, Zipline
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| 2025-07-29 |
Means and Meaning
We have the technology. Cool, now what?
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| 2025-07-25 |
Weekly Dose of Optimism #154
AI Action Plan, Aeneas, Genome Engineering, Male Contraceptive, FREP1, Zach Dell, New York
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| 2025-07-18 |
Weekly Dose of Optimism #153
Trump AI, Hyperion, Bedrock Robotics, IVF Threesome, GABA Labs, Reindustrialize, Floundering
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| 2025-07-17 |
How to Flounder Mode with Brie Wolfson
Hyperlegible 013: On Brie's good day together with Kevin Kelly
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| 2025-07-11 |
Weekly Dose of Optimism #152
Rainmaker, Moas, Robotic Surgeons, AI Taste, Nvidia, Everyday Wealth, Varda
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| 2025-07-09 |
Studying Peter Thiel and Founders Fund with Mario Gabriele
Hyperlegible 012: No Rivals, on the value of authenticity in writing and investing
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| 2025-07-04 |
Weekly Dose of Optimism #151
Hermeus, FAETON-I, Chai-2, Figma Files, 3I/ATLAS, Ambrook
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| 2025-07-03 |
America, the Beautiful
Watch now | A Founder's Letter follow-up + conversation with Ambrook's Mackenzie Burnett
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| 2025-07-01 |
The Great Differentiation
Salvation from Slop
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| 2025-06-27 |
Weekly Dose of Optimism #150
AlphaGenome, NY Nuclear, Shrooms, NewLimit, Tesla VPP, Cuby
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| 2025-06-24 |
Capital Intensity Isn't Bad
How Hard Tech Can Be More Capital Efficient Than Software
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| 2025-06-20 |
Weekly Dose of Optimism #149
Yeztugo, Verve, NYC Waymo, GENIUS Act, Synthetic Enzymes, Sari, Jason x Abundance
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| 2025-06-13 |
Weekly Dose of Optimism #148
Special Dan Wedding Day Packy Takeover: Childhood Leukemia, World Bank Nuclear, Standard Nuclear, Wayve + Uber, Tech Bonanza
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| 2025-06-10 |
Modern Magnificenza
How tech billionaires can restore our right-brain and make the world beautiful
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| 2025-06-06 |
Weekly Dose of Optimism #147
Exercise, Cilta-Cel, Neuralink, Embryo, Scientific Publishing, Amplify Bio
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| 2025-06-02 |
Crossing the Cringe Minefield with Cate Hall
Hyperlegible 010: On getting the thing you want by doing the thing you hate
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| 2025-05-30 |
Weekly Dose of Optimism #146
Pricey Healthy Babies, Zuck + Palmer, Porcine Kidneys, Radiant, Hermeus, Starship 9
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