Planet, space deliveries, delivery robots, AI scientists, bioelectricity, and bone glue
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2025-10-03 |
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Weekly Dose of Optimism #164
Planet, space deliveries, delivery robots, AI scientists, bioelectricity, and bone glue
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2025-10-01 |
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Thatch
Curing American healthcare through incentives and choice
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2025-09-26 |
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Weekly Dose of Optimism #163
Germinal (+bridge recombinase), cryo organs, Sila anodes, brain is not computer, hallucination-less psychedelics + Nate the Great
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2025-09-19 |
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Weekly Dose of Optimism #162
Meta Ray-Ban Display, World Labs, Waymo Safety, Colossus 2, Delphi-2M, Ambrook
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2025-09-12 |
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Weekly Dose of Optimism #161
Sapphire Canyon, Direct to Cell, Alterego, Soft Robots, Jetson Aero, AI Stuff
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2025-09-09 |
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Ramp at $1 Billion
Saving Time, Compounding Over Time, Fighting Time
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2025-09-05 |
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Weekly Dose of Optimism #160
Epigenetic atlas, Stroke Pills, Tempo, 1 GB Kuiper, Polymarket in the USA, Saquon
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2025-08-29 |
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Weekly Dose of Optimism #159
The Kelces, Starship, Pediatric CRISPR Cures, Nano Banana, Base, Electric Slide
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2025-08-26 |
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The Electric Slide
The history, 99% decline, and future of the Electric Stack with Sam D'Amico
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2025-08-22 |
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Weekly Dose of Optimism #158
Astro Mechanica, Convoke, Bloom Patterns, Electrochemical Nuclear, Mark Bertolini and Joe Liemandt
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2025-08-15 |
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Weekly Dose of Optimism #157
Advanced Nuclear, Vulcan Elemants, Rainmaker, Climate Catastrophism, AI-Designed Antibiotics + The Origins of Efficiency
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2025-08-08 |
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Weekly Dose of Optimism #156
Standard Nuclear, GPT-5, Genie 3, Eleven Music, Lithium Orotate
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2025-08-01 |
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Weekly Dose of Optimism #155
Personal Superintelligence, Iron-Air Batteries, OpenCRISPR-1, Figma, Zipline
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2025-07-29 |
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Means and Meaning
We have the technology. Cool, now what?
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2025-07-25 |
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Weekly Dose of Optimism #154
AI Action Plan, Aeneas, Genome Engineering, Male Contraceptive, FREP1, Zach Dell, New York
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2025-07-18 |
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Weekly Dose of Optimism #153
Trump AI, Hyperion, Bedrock Robotics, IVF Threesome, GABA Labs, Reindustrialize, Floundering
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2025-07-17 |
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How to Flounder Mode with Brie Wolfson
Hyperlegible 013: On Brie's good day together with Kevin Kelly
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2025-07-11 |
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Weekly Dose of Optimism #152
Rainmaker, Moas, Robotic Surgeons, AI Taste, Nvidia, Everyday Wealth, Varda
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2025-07-09 |
Studying Peter Thiel and Founders Fund with Mario Gabriele
Hyperlegible 012: No Rivals, on the value of authenticity in writing and investing
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2025-07-04 |
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Weekly Dose of Optimism #151
Hermeus, FAETON-I, Chai-2, Figma Files, 3I/ATLAS, Ambrook
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2025-07-03 |
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America, the Beautiful
Watch now | A Founder's Letter follow-up + conversation with Ambrook's Mackenzie Burnett
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2025-07-01 |
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The Great Differentiation
Salvation from Slop
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2025-06-27 |
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Weekly Dose of Optimism #150
AlphaGenome, NY Nuclear, Shrooms, NewLimit, Tesla VPP, Cuby
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2025-06-24 |
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Capital Intensity Isn't Bad
How Hard Tech Can Be More Capital Efficient Than Software
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2025-06-20 |
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Weekly Dose of Optimism #149
Yeztugo, Verve, NYC Waymo, GENIUS Act, Synthetic Enzymes, Sari, Jason x Abundance
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2025-06-13 |
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Weekly Dose of Optimism #148
Special Dan Wedding Day Packy Takeover: Childhood Leukemia, World Bank Nuclear, Standard Nuclear, Wayve + Uber, Tech Bonanza
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2025-06-10 |
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Modern Magnificenza
How tech billionaires can restore our right-brain and make the world beautiful
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2025-06-06 |
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Weekly Dose of Optimism #147
Exercise, Cilta-Cel, Neuralink, Embryo, Scientific Publishing, Amplify Bio
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2025-06-02 |
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Crossing the Cringe Minefield with Cate Hall
Hyperlegible 010: On getting the thing you want by doing the thing you hate
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2025-05-30 |
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Weekly Dose of Optimism #146
Pricey Healthy Babies, Zuck + Palmer, Porcine Kidneys, Radiant, Hermeus, Starship 9
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